USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P68366 USC-OGP 2-DE database:  P68366 P68366 General information about the entry View entry in simple text format Entry name TBA4A_HUMAN Primary accession number P68366 Secondary accession number(s) P05215 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tubulin alpha-4A chain; AltName: Full=Alpha-tubulin 1; AltName: Full=Testis-specific alpha-tubulin; AltName: Full=Tubulin H2-alpha; AltName: Full=Tubulin alpha-1 chain;. Gene name Name=TUBA4A Synonyms=TUBA1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0218: pI=4.91; Mw=21047 SPOT OGP-0236: pI=4.96; Mw=18897 SPOT OGP-0237: pI=5.02; Mw=18707 SPOT OGP-0241: pI=5.00; Mw=18211 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0359: pI=5.08; Mw=51589 SPOT OGP-0360: pI=5.06; Mw=51463 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0663: pI=5.07; Mw=52994 SPOT OGP-0664: pI=5.05; Mw=52731 Cross-references UniProtKB/Swiss-Prot P68366; TBA4A_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TBA4A_HUMAN Primary accession number P68366 Secondary accession number(s) A8MUB1 B3KNQ6 P05215 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  March 15, 2017 (version 141) Name and origin of the protein Description RecName: Full=Tubulin alpha-4A chain; AltName: Full=Alpha-tubulin 1; AltName: Full=Testis-specific alpha-tubulin; AltName: Full=Tubulin H2-alpha; AltName: Full=Tubulin alpha-1 chain; Gene name Name=TUBA4A Synonyms=TUBA1 Encoded on Name=TUBA4A; Synonyms=TUBA1 Keywords Acetylation; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Methylation; Microtubule; Neurodegeneration; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X06956; CAA30026.1; -; Genomic_DNA EMBL BT006731; AAP35377.1; -; mRNA EMBL AK054731; BAG51418.1; -; mRNA EMBL AK299958; BAH13182.1; -; mRNA EMBL AY895018; AAW65371.1; -; Genomic_DNA EMBL AC068946; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC114803; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471063; EAW70718.1; -; Genomic_DNA EMBL CH471063; EAW70719.1; -; Genomic_DNA EMBL BC009238; AAH09238.1; -; mRNA CCDS CCDS2438.1; -. [P68366-1]; . CCDS CCDS63131.1; -. [P68366-2]; . PIR A25873; A25873; . RefSeq NP_001265481.1; NM_001278552.1. [P68366-2]; . RefSeq NP_005991.1; NM_006000.2. [P68366-1]; . UniGene Hs.75318; -; . ProteinModelPortal P68366; -; . SMR P68366; -; . BioGrid 113128; 212; . IntAct P68366; 49; . MINT MINT-1394538; -; . STRING 9606.ENSP00000248437; -; . ChEMBL CHEMBL2095182; -; . DrugBank DB06772; Cabazitaxel; . DrugBank DB05147; CYT997; . DrugBank DB03010; Epothilone B; . DrugBank DB01873; Epothilone D; . DrugBank DB01179; Podofilox; . DrugBank DB05281; S-8184; . DrugBank DB00541; Vincristine; . iPTMnet P68366; -; . PhosphoSitePlus P68366; -; . SwissPalm P68366; -; . DMDM 55977476; -; . DOSAC-COBS-2DPAGE P68366; -; . OGP P05215; -; . EPD P68366; -; . MaxQB P68366; -; . PaxDb P68366; -; . PeptideAtlas P68366; -; . PRIDE P68366; -; . DNASU 7277; -; . Ensembl ENST00000248437; ENSP00000248437; ENSG00000127824. [P68366-1]; . Ensembl ENST00000392088; ENSP00000375938; ENSG00000127824. [P68366-2]; . GeneID 7277; -; . KEGG hsa:7277; -; . UCSC uc002vkt.3; human. [P68366-1]; . CTD 7277; -; . DisGeNET 7277; -; . GeneCards TUBA4A; -; . HGNC HGNC:12407; TUBA4A; . HPA CAB004621; -; . HPA CAB005887; -; . HPA HPA039247; -; . HPA HPA043684; -; . HPA HPA063394; -; . MalaCards TUBA4A; -; . MIM 191110; gene; . MIM 616208; phenotype; . neXtProt NX_P68366; -; . OpenTargets ENSG00000127824; -; . PharmGKB PA162407391; -; . eggNOG KOG1376; Eukaryota; . eggNOG COG5023; LUCA; . GeneTree ENSGT00760000119060; -; . HOGENOM HOG000165711; -; . HOVERGEN HBG000089; -; . InParanoid P68366; -; . KO K07374; -; . OMA SEGREDM; -; . OrthoDB EOG091G0736; -; . PhylomeDB P68366; -; . TreeFam TF300314; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-190840; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; . Reactome R-HSA-190861; Gap junction assembly; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2500257; Resolution of Sister Chromatid Cohesion; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-380320; Recruitment of NuMA to mitotic centrosomes; . Reactome R-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; . Reactome R-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC; . Reactome R-HSA-389977; Post-chaperonin tubulin folding pathway; . Reactome R-HSA-437239; Recycling pathway of L1; . Reactome R-HSA-5610787; Hedgehog 'off' state; . Reactome R-HSA-5617833; Cilium Assembly; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-5620924; Intraflagellar transport; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-6807878; COPI-mediated anterograde transport; . Reactome R-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic; . Reactome R-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic; . Reactome R-HSA-68877; Mitotic Prometaphase; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . Reactome R-HSA-983189; Kinesins; . SIGNOR P68366; -; . ChiTaRS TUBA4A; human; . GeneWiki TUBA4A; -; . GenomeRNAi 7277; -; . PMAP-CutDB P68366; -; . PRO PR:P68366; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000127824; -; . CleanEx HS_TUBA4A; -; . ExpressionAtlas P68366; baseline and differential; . Genevisible P68366; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0015630; C:microtubule cytoskeleton; IDA:HPA; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0003924; F:GTPase activity; IEA:InterPro; . GO GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0007017; P:microtubule-based process; IEA:InterPro; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . Gene3D 1.10.287.600; -; 1; . Gene3D 3.30.1330.20; -; 1; . Gene3D 3.40.50.1440; -; 1; . InterPro IPR002452; Alpha_tubulin; . InterPro IPR008280; Tub_FtsZ_C; . InterPro IPR000217; Tubulin; . InterPro IPR018316; Tubulin/FtsZ_2-layer-sand-dom; . InterPro IPR023123; Tubulin_C; . InterPro IPR017975; Tubulin_CS; . InterPro IPR003008; Tubulin_FtsZ_GTPase; . PANTHER PTHR11588; PTHR11588; 1; . Pfam PF00091; Tubulin; 1; . Pfam PF03953; Tubulin_C; 1; . PRINTS PR01162; ALPHATUBULIN; . PRINTS PR01161; TUBULIN; . SMART SM00864; Tubulin; 1; . SMART SM00865; Tubulin_C; 1; . SUPFAM SSF52490; SSF52490; 1; . SUPFAM SSF55307; SSF55307; 1; . PROSITE PS00227; TUBULIN; 1; .

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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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